DNAJB1 and tauopathy: In contrast, DNAJA2 and DNAJB1 remained effective in suppressing the aggregation of the P301L variant of tau4R (with the anti-aggregation activity of DNAJB1 being even higher for this tauopathy mutant, Figure 4—figure supplement 4C), indicating that these Hsp40 chaperones could be effective in suppressing a wide range of tauopathies.