West Nile virus (WNV) upregulates cholesterol synthesis to promote its replication; on the contrary, reducing cholesterol production by HMGCR inhibition had an inhibitory effect on WNV replication.8 Hepatitis C virus (HCV) infection leads to the activation of nuclear factor-κB (NF-κB) which can induce the expressions of heparan sulfate proteoglycans (HSPGs) for the upregulations of cholesterol uptake and HCV entry.34 Nevertheless, not all viruses adopts the strategy of increasing cholesterol metabolism. This evidence concerns the gene HMGCR and infection.