Knockout, inhibition or neutralization of IL‐36γ significantly inhibits NSCLC progression and prolongs survival of the KrasLSL‐G12D/+Tp53fl/fl and KrasLSL‐G12D/+Lkb1fl/fl mice after tumor induction, reduces GSH levels and increases oxidative stress in the tumors and promotes tumor cell death, whereas knockout of IL‐36Ra has opposite effects. Here, IL36RN is linked to non-small cell lung carcinoma.