Single‐cell mRNA transcriptome analysis revealed that Il1f9 was primarily expressed in neutrophils, Il1f5 (encoding IL‐36Ra) was highly expressed in endothelial cells, neutrophils, and Lyz2+ mono‐macrophages/dendritic cells (mono‐φ/DCs), and Il1rl2 (encoding IL‐36R) was expressed in endothelial cells, epithelial tumor cells, and neutrophils in lung tumors from KL mice (Figure S2A–E, Supporting Information). This evidence concerns the gene IL36RN and neoplasm.