Knockout, inhibition or neutralization of IL‐36γ significantly inhibits NSCLC progression and prolongs survival of the KrasLSL‐G12D/+Tp53fl/fl and KrasLSL‐G12D/+Lkb1fl/fl mice after tumor induction, reduces GSH levels and increases oxidative stress in the tumors and promotes tumor cell death, whereas knockout of IL‐36Ra has opposite effects. The gene discussed is IL36G; the disease is non-small cell lung carcinoma.