In addition, the tumor progression was accelerated in KL and KL9 mice by the antioxidant NAC to a similar level of that in KL5 mice treated with saline, and NAC treatment did not affect NSCLC progression in KL5 mice, indicating that IL‐36γ and IL‐36Ra reciprocally regulate NSCLC progression by modulating the ROS levels and oxidative stress. This evidence concerns the gene IL36RN and non-small cell lung carcinoma.