Importantly, AZD4547/BI6727 combination remarkably upregulated ROS in murine KP cells (KRASG12D, p53−/−) derived from Kras‐mutant lung adenocarcinoma, and the presence of HCQ further increased AZD4547/BI6727‐induced ROS levels in KP cells (Appendix Fig S5E), reinforcing our in vitro results. Here, TP53 is linked to lung adenocarcinoma.