We noticed that genetic depletion of FGFR1 increased PLK1 activity and PLK1 reduction upregulated FGFR1 in KRAS‐mutant lung and pancreatic cancer cells (Appendix Fig S2F and G), suggesting that FGFR1‐ and PLK1‐mediated pathways reciprocate in KRAS‐mutant lung cancer. Here, PLK1 is linked to familial pancreatic carcinoma.