In contrast, BI2536 alone was sufficient to induce high levels of ROS in KRAS‐mutant colon cancer cells (SW620) and addition of AZD4547 failed to further increase BI2536‐induced ROS in the cells (Appendix Fig S4F), whereas in KRAS‐WT lung cancer cells (EBC‐1), the combination only slightly elevated ROS compared to single agents (Appendix Fig S4F). This evidence concerns the gene KRAS and lung carcinoma.