On the other hand, DOX‐activated ROS affects the cleavage of Caspase‐8; the c‐Caspase‐8 would promote the cleavage of Caspase‐3, the c‐Caspase‐3 will induce the cleavage of GSDME, and triggered pyroptosis of breast cancer cells (Figure 5). This evidence concerns the gene GSDME and breast cancer.