GSDME and breast carcinoma: On the other hand, DOX‐activated ROS affects the cleavage of Caspase‐8; the c‐Caspase‐8 would promote the cleavage of Caspase‐3, the c‐Caspase‐3 will induce the cleavage of GSDME, and triggered pyroptosis of breast cancer cells (Figure 5).