Reproductive defects are the most consistent phenotypes seen in FA mouse models [Fanca−/−, Fancb−/−  Fancc−/−, Fancd1, Fancd2−/−, Fance−/−, Fancg−/−, Fancj−/−, Fancl−/−, Fancm−/− and Fancp−/− (18–22)]. Here, BRIP1 is linked to Friedreich ataxia.