Using a microfluidic chip-based analysis, it was found that sera-derived EVs from GBM patients (small cohort study) are enriched in mRNA levels of MGMT (O6-methylguanine DNA methyltransferase) and APNG (alkylpurine-DNA-N-glycosylase), primary DNA repair enzymes involved in inducing chemoresistance[210]. This evidence concerns the gene MGMT and glioblastoma.