Other studies showed that exosome-induced cytokine secretion is compromised in CD14++ monocytes from ALS patients, and this abnormality is modulated by exosomal TDP-43, suggesting that exosomal TDP-43 contributes to the impaired neuroinflammatory reaction in ALS pathogenesis[134]. The gene discussed is CD14; the disease is amyotrophic lateral sclerosis.