SHBG and obesity due to melanocortin 4 receptor deficiency: Postulated mechanisms forprotection in postmenopausal obese women include increased adipose tissuearomatization of androstenedione, secreted from the adrenal glands, into bioactiveestrone that maintains or increases bone mass [56,57]; greater weight-bearingconcurrent with obesity [56,57]; and the decreased SHBG in obesity that is associatedwith higher circulating free sex steroids and hyperinsulinemia.