Thus, P4rr reduced fetal liver βGlcCer, pup lung βGlcCer, pup liver βGlcCer, OVA-specific IgE, and the pup allergen-induced allergic inflammation, consistent with the P4rr-mediated reduced numbers of resident DCs in the fetal liver and pup lungs and demonstrating that βGlcCer was necessary for the increased allergen-induced lung eosinophilia in offspring of allergic mothers. This evidence concerns the gene IGHE and Increased total eosinophil count.