In addition, DKK‐1 enhances secretion of sclerostin(37) and increases the RANKL/OPG ratio, resulting in increased osteoclastogenesis.(38) Several other Wnt pathway regulatory factors including periostin, Runt‐related transcription factor 2, and Growth factor independence 1 are also deregulated in MM.(24). The gene discussed is SOST; the disease is Miyoshi myopathy.