Osteocytes are shown to activate Notch signaling via Notch3, which leads to increased MM cell proliferation, and has the capacity to change the Notch receptor repertoire expressed by MM cells.(23) In vivo studies inhibiting Notch signaling, alone or in combination with other anti‐apoptotic treatment led to the inhibition of MM cell growth.(43, 44). The gene discussed is NOTCH3; the disease is Miyoshi myopathy.