HMGCR and type 2 diabetes mellitus: In the same study, using mendelian randomisation, the researchers showed that reduced HMG-CoA-reductase activity marginally increased T2DM risk (rs17238484-G allele OR per allele 1.02, 95% CI 1.00–1.05; rs12916 allele 1.06, 95% CI 1.03–1.09), thus inferring that statins partly confer an increased T2DM risk.