Although exercise is proven to be beneficial for sarcopenia, increasing muscle anabolism by modulating metabolic regulators of AKT and mTOR, and mitochondrial regulators of SIRT3, AMPK and PGC-1a [33,39], the reality is that exercise is challenging for old people and may even be dangerous for frail elderly who suffer sarcopenia. This evidence concerns the gene PPARGC1A and sarcopenia.