Generally, NNMT activity or expression is significantly elevated in cancers, such as brain [68], lung [69], liver [70], kidney [71, 72], bladder [73], stomach [74, 75], pancreas [76], colon [77], and oral [78, 79] cancer but cancer cells usually have a significantly higher anaerobic metabolism rate than normal cells. The gene discussed is NNMT; the disease is cancer.