As the lack of homogeneous grouping based on the antibody profiles perturbs the diagnostic, therapeutic, and prognostic stratification of these patients, exosome-derived miRNAs of circulating plasma were profiled in the present study using next-generation sequencing (NGS) from two subsets of DM patients: patients with DM complicated with ILDs prior to treatment with circulating anti-MDA5 Ab-positive status [DM-ILD-MDA5 Ab(+)] and patients without ILDs who were negative for 16 detectable MSA [DM-nonILD-MSA16(-)]. This evidence concerns the gene IFIH1 and dermatomyositis.