In the present study, hsa-miR-4488 was significantly upregulated in DM-ILD-MDA5 Ab(+) when compared to DM-nonILD-MSA16(-) and HC, suggesting that miR-4488 may contribute to systemic inflammation in DM-ILD-MDA5 Ab(+) by upregulating NF-κB signaling through repression of DDX39B. The gene discussed is IFIH1; the disease is dermatomyositis.