Taken together, our results have demonstrated that first, tumor promoter IKK2 and tumor suppressor Tp53 significantly modulate the expressions of OCRGs; second, lung tumor LUAD-downregulated vesicle regulator PLIN4 may contribute to IKK2 KO-promoted tumor formation; third, liver tumor (LIHC)-upregulated vesicle regulator P4HA2 may increase Tp53 KO-promoted liver tumorigenesis; and fourth, LIHC-downregulated vesicle regulator AASS may contribute to Tp53 suppression of liver tumorigenesis. This evidence concerns the gene IKBKB and neoplasm.