APOE and hyperlipidemia: Of note, oscillatory shear vs. laminar shear (fibrosa), oscillatory shear vs. laminar shear (ventricularis) (97), and MAECs from atherogenic apolipoprotein E (ApoE)-deficient mice vs. MAECs from wild-type control mice had no modulation of OCRG expressions potentially due to a long-term chronic adaptation process in response to shear stress or hyperlipidemia.