As shown in Figures 2A–D, in 26 upregulated OCRGs in AIs, the upregulation of two regulators, SERPINA1 and AZU1, was shared among acute respiratory distress syndrome (ARDS), sepsis, and trauma; upregulation of CD24 and FKBP8 was shared among ARDS and trauma; and upregulation of GRN was shared between sepsis and trauma. The gene discussed is AZU1; the disease is Sepsis.