INS and fragile X syndrome: In weakened Treg when Treg signature genes are deficient, upregulated OCRGs are more than downregulated OCRGs; and (3) positive regulation of macroautophagy, regeneration, regulation of protein stability, positive regulation of apoptotic process, and leukocyte chemotaxis signaling are upregulated in Treg; and regulation of autophagy, adaptive immune system, Fragile X syndrome, insulin secretion, lipid transport, and organic hydroxy compound metabolic process are upregulated in weakened Treg.