The cancer gene expression database analysis showed that the expressions of vesicle regulator P4HA2 were increased in seven out of 33 tumor types compared with controls (Supplementary Figure 16D); and the expression of vesicle regulator AASS in seven out of 33 tumor types was decreased compared with that of controls (Supplementary Figure 16E). The gene discussed is P4HA2; the disease is neoplasm.