In 80 upregulated OCRGs in ADs, three regulators (i.e., GPRC5A, LAMP3, and MX2) were shared among RA, autoimmune skin disease (ASD), and inflammatory bowel disease (IBD); three regulators (i.e., OSBPL8, SERPINA1, and MX1) were shared between RA and IBD; seven regulators (i.e., PPARG, MYO19, MAP1LC3A, TLR9, NACC1, P4HA2, and SAMD9) were shared between RA and ASD; and four regulators (i.e., POU2F2, VMP1, ATP11A, and KDR) were shared between ASD and IBD. This evidence concerns the gene SERPINA1 and inflammatory bowel disease.