JAK2 knockdown (KD) in human acute myelogenous leukemia (AML) cell line, STAT1 KD in human T cell acute lymphocytic leukemia cells, Stat3 KD in mouse mammary tumor, and STAT3 KD in human urothelial cancer cells resulted in zero to two OCRG upregulation and one to five OCRG downregulations. The gene discussed is STAT3; the disease is breast cancer.