SCD and cancer: In ovarian cancer cells, overexpression of stearoyl-CoA desaturase 1 (SCD1), an essential enzyme in biosynthesis of MUFAs, shows resistance to ferroptosis (57); besides, SCD1 expressed by cancer cells leads to fatty acid (FA) desaturation and contributes to the protection of oxidative stress-induced ferroptosis, eventually promoting tumor recurrence (58).