It is worth noting that measuring sST2 combined with BNP or NT-proBNP is better than merely measuring NT-proBNP, because sST2 has a better predictive value than NT-proBNP in myocardial fibrosis and remodeling, which is a known indicator of HF severity (65, 66). The gene discussed is NPPB; the disease is Myocardial fibrosis.