This study highlights the dysregulations of lncRNA ENSMUST00000155383-associated genes in the vascular endothelium and demonstrated that MK-626 may improve vascular endothelial function in hypertension through upregulating lncRNA ENSMUST00000155383, restoring Ca2+ entry mediated through Cacna1c, subsequently enhancing eNOS activity (Figure 8). Here, NOS3 is linked to hypertensive disorder.