In order to further clarify the role of lncRNA ENSMUST00000155383 and the regulation of MK-626 on lncRNA ENSMUST00000155383 in hypertension-related endothelial dysfunction, we used siRNA delivery and achieved >60% reduction in the expression of lncRNA ENSMUST00000155383 in the aortic ECs from Ang II and MK-626 co-treatment mice (Supplementary Figure S5). Here, AGT is linked to hypertensive disorder.