M2-Exos carrying miR-148a alleviates myocardial ischemia/reperfusion (MI/R) injury by down-regulating thioredoxin-interacting protein (TXNIP) and through inactivation of the TLR4/NF-κB/NLRP3 inflammasome signaling pathway (Dai et al., 2020). This evidence concerns the gene TXNIP and myocardial ischemia.