The driver genes ERBB2, HDAC1, PARP1, ERBB3, FGFR3, mTOR, AXL, EZH2, FGFR1, FGFR2, CSF1R, KIT, FGFR4, RET, and ERBB4 are key targets in the treatment of BLCA. This evidence concerns the gene HDAC1 and bladder transitional cell carcinoma.