The heat map with the gene expression profile of these six homeobox genes showed that ISL1, ZFHX4, TSHZ3, and ZEB2 were more highly expressed in high-risk BLCA samples, while HOXC4 and MEIS1 were highly expressed in the low-risk group (Figure 4E). This evidence concerns the gene ZFHX4 and bladder transitional cell carcinoma.