Therefore, to further verify whether CEACAM-1 and TIM-3 were involved in HNSCC progression and their expression profile in HNSCC patients, we measured the expression of CEACAM1 and TIM-3 in HNSCC tissues, and evaluated the combinational clinical significance of CEACAM1 and TIM-3 for the prognosis and treatment decision making in HNSCC. This evidence concerns the gene CEACAM1 and head and neck squamous cell carcinoma.