Univariate analysis showed that OS has significant correlation with TNM stage (p = 0.001), tumor size (p = 0.019), lymph node metastasis (p < 0.001), TIM-3+ TILs infiltration (p < 0.001), CEACAM1+ TILs count (p = 0.015), and cancer cells expressed CEACAM1 (p < 0.001), while DFS was directly influenced by histologic grading (p = 0.045), TNM stage (p = 0.001), tumor size (p = 0.016), lymph node metastasis (p = 0.002), TIM-3+ TILs infiltration (p < 0.001), CEACAM1+ TILs count (p = 0.011), and cancer cells expressed CEACAM1 (p < 0.001). This evidence concerns the gene HAVCR2 and cancer.