CEACAM1 and carcinoma: Figures 1D,F showed that TIM-3+ TILs highly correlated with co-infiltration of CEACAM1+TILs and CEACAM1 expression on carcinoma cells. Results were consistent with other reported studies and implied that TIM-3 was co-expressed with CEACAM1 and involved in T-cell inhibition. What’s more, Huang et al. (2015) found that CEACAM1-deficient T cells were hyperinflammatory with reduced cell surface expression of TIM-3 and regulatory cytokines, and this was restored by T-cell-specific CEACAM1 expression.