In this Ying-Yang model, while DNp73 possesses oncogenic properties that include impairment of the DNA damage-response pathway, cellular immortalization, as well as a dominant negative function of the p53/TAp73-canonical functions (Petrenko et al., 2003; Wilhelm et al., 2010; Billant et al., 2016), TAp73 tumor suppressor activity mainly relies on p53-canonical functions, like its ability to induce cell cycle arrest, apoptosis or regulation of DNA damage response, as well as other functions like immune cell regulation (Tomasini et al., 2008; Costanzo et al., 2014; Wolfsberger et al., 2021). This evidence concerns the gene TP53 and neoplasm.