Mesenchymal stem cell exosome-derived lncRNAs such as H19 shuttle between MSCs and fibroblasts to perform their function in facilitating wound healing in diabetic foot ulcers (Li et al., 2020), which indicates that MSC-derived exosomes with lncRNA overexpression might be a novel direction for developing cell-free therapeutic strategies and will improve MSC efficacy. The gene discussed is H19; the disease is diabetic foot.