(1) Function as a scaffold to enhance the interaction between TRIM25 and IGF2BPs, from a TRIM25/circNDUFB2/IGF2BPs ternary complex and facilitate ubiquitination and degradation of IGF2BPs. (2) Participate in the activation of anti-tumor immunity by activating the RIG-I–MAVS pathway. The gene discussed is RIGI; the disease is neoplasm.