AKT1 and cancer: Pathway analysis results also showed that the genes located in breakpoint regions are strongly associated with various cancer-mediated pathways such as TP53 network, GPCRs Class B Secretin-like pathway, p38 MAPK signaling pathway, apoptosis-related network in ovarian cancer, Notch signaling pathway, PDGF pathway, and IGF1-Akt signaling (Steller et al., 1996; Serrano et al., 2008; Chen, 2015; Wu et al., 2017).