Zhang et al. (2020) revealed that CCL8 (also referred to as MCP-2) delivered by TAMs promoted invasion and GBM cells stemness by mobilizing the phosphorylation of ERK1/2 in GBM cells. Severa et al. (2014) recorded the transcriptional repressor B lymphocyte-induced maturation protein 1 (BLIMP1) conditional knockout (CKO) mice showed stronger levels of circulating CCL8, uncovering that BLIMP1 performed a fundamental task in modifying host defense mechanisms by decreasing CCL8-expression. The gene discussed is PRDM1; the disease is glioblastoma.