PROS1 and neoplasm: Tumor microenvironment (TME) composing of cancer cells, infiltrating immune cells, endothelial cells, pericytes, fibroblasts, extracellular matrix (ECM) proteins and cytokines, is a complex cellular ecological environment, which evolves together with tumor cells and provides support throughout the transmutation to malignancy (Radin and Tsirka, 2020).