CCL5 and CCL18 up-regulate the activity of various glycolysis factors, including lactate dehydrogenase A (LDHA) and glucose-6-phosphate dehydrogenase (G6PD), which can advance glycolysis in tumor cells, lead to accumulation of lactic acid in TME and restrain the immune system’s anti-tumor reaction (Colegio et al., 2014). This evidence concerns the gene CCL5 and neoplasm.