In the process of glioblastoma, TAMs are recruited and induced by cancer cells to enhance tumor development (Mantovani et al., 2002), that is, tumor cells inhibit the anti-tumor immunological reaction of TAMs and urge TAMs to secret IL-6, VEGF, MMPs, IL-10 and TGF-β1 to favor tumor cell expansion, angiogenesis, matrix degradation and invasion (Joseph et al., 2015). This evidence concerns the gene VEGFA and neoplasm.