VEGFA and neoplasm: During the development of the tumor, the newly generated blood arteries sustain oxygen and nutrition to tumor, authorizing it to grow and invade while macrophages secrete angiogenesis-promoting growth substances such as vascular epithelial growth factor (VEGF)-family members, CSF1, WNT family members etc., speeding the degradation of the perivascular extracellular matrix to assist tumor angiogenesis (De Palma et al., 2017).