KLF15 affects myocardial hypertrophy by inhibition of MEF2 and GATA4 transcription (Zhao et al., 2019), and can reduce myocardial fibrosis by down-regulating the expression of transforming growth factor-β (TGF-β), connective tissue growth factor, and myocardial protein-associated transcription factor-A in myocardial fibroblasts (Zhao et al., 2019). This evidence concerns the gene GATA4 and Myocardial fibrosis.