Expression of ABCA3, CTGF, and AMIGO2 were significantly higher in metastatic osteosarcoma samples compared to the primary osteosarcoma samples (Supplementary Figures 1A–C) while the expression of PREB, FHIT, and EXOSC5 were significantly decreased in metastatic osteosarcoma samples (Supplementary Figures 1D–F). The gene discussed is EXOSC5; the disease is osteosarcoma.