RNF19B and neoplasm: Studies conducted in our laboratory with NKLAM-deficient mice indicate that NKLAM is required for maximal NK-mediated anti-tumor function and for suppression of tumor dissemination and metastasis in vivo (Portis et al., 2000; Fortier and Kornbluth, 2006; Hoover et al., 2012; Lawrence et al., 2020).