Interestingly, positively correlated loci represented cancer driver genes (MYC, PRKCD, RB1, CDK6), molecules involved in immune response (MALT1, PIK3CG), as well as cellular and hormonal signaling (HGF, PTPN13, IGF1, SMAD1, ESR1, CTGF). The gene discussed is RB1; the disease is cancer.