ADAM8 and chronic pancreatitis: With miRNA-451 detecting precursor lesions and PDAC, but not chronic pancreatitis (CP) and mi-RNA 720 detecting CP but not precursor lesions in conjunction with ADAM8-positive EVs, we can achieve a high degree of specificity and sensitivity in serum EV analysis to predict pancreatic precursor lesion and PDAC while discriminating between chronic pancreatitis patients and healthy individuals.