Since ADAM8 expression is high in PDAC, it is likely that EVs isolated from its precursor lesions, Pancreatic intraepithelial Neoplasia (PanINs) types 2 and 3, could be packed with ADAM8 and ADAM8-associated molecular markers such as miRNAs as shown for breast cancer with correlated expression levels of ADAM8 and miRNA-720 (Das et al., 2016). Here, ADAM8 is linked to breast carcinoma.