Here we hypothesized that high ADAM8 expression levels in pancreatic cancer is reflected by release of EVs expressing ADAM8 on their surface and that ADAM8 expression might cause miRNAs associated with ADAM8 expression to be cargo for ADAM8-positive EVs, so that these EVs can be used to detect pancreatic cancer in patient serum at early stages. Here, ADAM8 is linked to pancreatic neoplasm.