Several studies have demonstrated how LCSCs can be differentiated from liver cancer cells by targeting the cluster of differentiation markers CD13 (Haraguchi et al., 2010), CD44 (Zhu et al., 2010), CD90 (Yang Z. F. et al., 2008), CD133 (You et al., 2010); epithelial cell adhesion molecule (EpCAM) (Jin et al., 2011); and keratin 19 (Van Haele et al., 2019). This evidence concerns the gene PROM1 and liver cancer.