Mokkapati et al. (2014) reported that β-catenin activation in LCSCs caused HCC development with spontaneous lung metastases. Wnt/β-catenin signaling is activated following nuclear translocation of the β-catenin components Shp2 (Xiang et al., 2017), c-Myc (He et al., 1998), and EpCAM (Yamashita et al., 2007). This also leads to the enrichment of CD133 + (Ma et al., 2007), EpCAM + (Yamashita et al., 2009) and OV6 + (Yang W. et al., 2008) LCSCs that contribute to tumor growth and chemoresistance. This evidence concerns the gene PROM1 and hepatocellular carcinoma.