For example, DDX3, a member of the DEAD-box RNA helicase family (Schroder, 2010), represses stemness in HCC by epigenetically modulating tumor-suppressive miRNAs (including miR-200b, miR-200c, miR-122, and miR-145) (Li H. K. et al., 2016). This evidence concerns the gene DDX3X and neoplasm.