SETD7 and liver cancer: He et al. (2013) successfully induced mature hepatocytes to dedifferentiate into HCC progenitor cells in a mouse liver cancer model by stimulating damaged liver cells with interleukin (IL-6). Nikolaou et al. (2015) used a PR-SET7-deleted experimental mouse model of liver cancer to show that promoting hepatocyte microtubule expansion can facilitate the transformation of normal liver cells into liver cancer cells.