Ling Qi and colleagues demonstrated that lncCAMTA1 physically associates with the calmodulin-binding transcription activator 1 (CAMTA1) promoter, induces a repressive chromatin structure, and inhibits CAMTA1 transcription, thereby promoting HCC cell proliferation, CSC-like properties, and tumorigenesis. The gene discussed is CAMTA1; the disease is hepatocellular carcinoma.