SIRT5 has been reported to exhibit a protective role in the pathological process of AMI, as global knockout of SIRT5 increased the infarct size in a model of cardiac ischemia-reperfusion injury (Boylston et al., 2015) and developed heart failure (Sadhukhan et al., 2016). The gene discussed is SIRT5; the disease is myocardial ischemia.