Furthermore, the Tg(ziwi:CFP-NTR) transgenic background females reverted into the fertile males after most of ovarian gem cells were ablated by MTZ treatment (Figure 1B) (Dranow et al., 2013, 2016), while the Tg(vasa:dendra2-NTR) transgenic line females failed to regenerate and finally reverted into the infertile males when the early stage germ cells were ablated by MTZ (Figure 1C) (Cao et al., 2019). Here, NTSR1 is linked to Infertility.