STIM1 knockdown in cardiomyocytes causes SAN dysfunction, reduction in heart rate, arrhythmias and lethality in adult mice (Ohba et al., 2009; Zhang et al., 2015) while STIM1 overexpression in the heart leads to aberrant calcium handling and lethal cardiomyopathy (Correll et al., 2015). This evidence concerns the gene STIM1 and cardiomyopathy.