TAC-induced cardiac hypertrophy exhibited expansion of circulating Ly6Chigh and Ly6Clow monocytes and pro-inflammatory CD206– cardiac macrophages at 1 week after surgery, prior to significant cardiac hypertrophy and dysfunction (Weisheit et al., 2014, 2021; Nemska et al., 2016; Patel et al., 2017, 2018; Liao et al., 2018; Figure 1B). This evidence concerns the gene MRC1 and cardiac hypertrophy.