In HF-prone hypertensive Ren-2 rats that carry two copies of the mouse renin-2 gene and exhibit moderate hypertension, myocardial hypertrophy, and excessive fibrosis likely due to Ang-II overproduction, intravenous administration of liposomal CL selectively depleted blood monocytes and myocardium macrophages. This evidence concerns the gene AGT and Hypertension.