ITGAM and Interstitial cardiac fibrosis: In mice, S100a8/a9 neutralization with its antibody blocked Ang-II infusion-induced NF-κB activation, inflammatory cell (CD45+, CD11b+, CD45+CD11b+, and Gr1+ cells) infiltration, and cytokine (IL1β and TNF-α) and chemokine (CCL2, CCL3, CCL5, and CCL7) production, in addition to reduced cardiac interstitial fibrosis and cardiac cell hypertrophy (Wu et al., 2014; Figure 4).