CMA1 and cardiac hypertrophy: Estrogen (17β-estradiol) replacement, chymase inhibition with chymostatin, or MC stabilization with nedocromil reduced pressure overload-induced ventricular hypertrophy in ovariectomized rats, along with reduced myocardial chymase, TGF-β1, and MC contents, and plasma chymase levels (Li et al., 2015).