JAK2 and cancer: Due to the heterogeneity and genetic instability of cancer, AGK seems to play a core role in cancer progression through different signaling pathways and molecules, such as the Hippo-YAP1, JAK2/STAT3, nuclear factor-kappa B (NF-κB), and PI3K/protein kinase B (Akt) signaling pathways as well as the forkhead box O1 (FOXO1) and epidermal growth factor (EGF) transcription factors (Figure 7).