On the one hand, AGK, as the upstream matrix of Yes-associated protein 1 (YAP1), can induce the nuclear localization of YAP1 to enhance the transcriptional activity of YAP1/transcriptional enhanced associate domain (TEAD)s, and eventually lead to the proliferation, invasion, and epithelial–mesenchymal transition of cancer cells (Huang et al., 2020). The gene discussed is AGK; the disease is cancer.