MSC-Nanog-CM accelerated the telogen-to-anagen transition in HFs and increased HF density to a greater extent than MSC-CM. The expression of DP and HF stem cell markers and genes related to hair induction were higher in MSC-Nanog-CM than in AF-MSC-CM. Paracrine factors contained in MSC-Nanog-CM. The gene discussed is NANOG; the disease is Hand-foot syndrome.