CRP and Increased total leukocyte count: As the size of the PPE increases, other variables related to its severity and to the intensity of treatment simultaneously increase, such as leukocytosis with neutrophilia, C-reactive protein, sodium (decrease) and urea values in the blood, growth of evident pathogenic organisms in the cultures, CTPD placement, need for oxygen therapy, admission to intensive care, and the length of fever, antibiotic treatment and LHS.