The genomic alteration landscape of 24 cases of IPMN was characterized by GNAS (n = 13, 54.17%), KRAS (n = 13, 54.17%), MUC17 (n = 11, 45.83%), POLE (n = 9, 37.50%), and TP53 (n = 7, 29.17%) (Supplementary Figure 1B). This evidence concerns the gene POLE and pancreatic intraductal papillary-mucinous neoplasm.