Furthermore, the investigation of the cell-cell interactions suggested that C2_CD8+ T cells are able to communicate with osteoblastic OS cells; in particular, associations were identified between IFNG_ type II IFNR and PDCD1-FAM3C, which are representative of C2_CD8+ T cells mediating the immune response to tumor cells via IFN-γ. This evidence concerns the gene PDCD1 and neoplasm.