AKT1 and breast carcinoma: To further investigate function of PTK7 in EGFR-PI3K-Akt signaling pathway in breast cancer, we performed PTK7 and EGFR pair-wise gene correlation analysis using GEPIA (Figure 4C) and further confirmed EGFR expression positively correlated with PTK7 (R = 0.42, P = 2e-48).