The purpose of this study was to examine the effects of candidate SNPs that were previously confirmed by genome-wide association and independent replication studies of serum adiponectin levels on breast cancer risk among AA postmenopausal women, who are vulnerable to both high incidence of obesity and breast cancer risk, using a large prospective cohort study from the Women’s Health Initiative (WHI) (23, 26, 27, 29–35). This evidence concerns the gene ADIPOQ and breast carcinoma.