Additionally, SNHG16 can serve as an endogenous sponge of miR-140-5p and up-regulate flap endonuclease 1 (FeN1), an oncogene in a range of cancers, which is also involved in the pathological process of HCC, thereby reducing the sensitivity of HCC cells to sorafenib and affecting the therapeutic effect (49). This evidence concerns the gene FEN1 and cancer.