Furthermore, circRNA-SORE can bind to YBX1, a major oncogenic protein in cytoplasmic matrix, thereby preventing YBX1 from interacting with E3 ubiquitin ligase PRP19, blocking PRP19-mediated degradation of YBX1, stabilizing YBX1, and ultimately mediating sorafenib resistance in HCC cells and poor prognosis of patients (96). This evidence concerns the gene PRPF19 and hepatocellular carcinoma.