IGF1R and hepatocellular carcinoma: Furthermore, enhancers of zeste 2 multimeric complex 2 subunit (EZH2) inhibit HCC cell apoptosis and promote sorafenib resistance by suppressing the expression of miR-101, miR-122, miR-125b and miR-139 thereby regulating insulin-like growth factor 1 receptor (IGF1R) levels (39).