FEN1 and hepatocellular carcinoma: Additionally, SNHG16 can serve as an endogenous sponge of miR-140-5p and up-regulate flap endonuclease 1 (FeN1), an oncogene in a range of cancers, which is also involved in the pathological process of HCC, thereby reducing the sensitivity of HCC cells to sorafenib and affecting the therapeutic effect (49).