Upregulation of VTCN1 expression in lung carcinoma is strongly associated with lymph node metastasis and the TNM stage, and VTCN1 can facilitate the growth and proliferation of tumor cells by upregulating the expression of Bax and caspase3/8 and by downregulating that of Bcl-2 and cyclin_D1 (91). The gene discussed is VTCN1; the disease is neoplasm.