PDCD1 and non-small cell lung carcinoma: Two agonist antibodies, namely urelumab (BMS-663613) and utomilumab (PF-05082566), can be used in synergy with anti-CD20 and anti-PD-1 mAbs and are under study in clinical trials for the confirmation of their therapeutic effect on metastatic melanoma and advanced solid tumors, especially NSCLC and renal cell carcinoma (121).