Similarly, the combination of TNFSF4 (OX40L) fusion protein and poxvirus-based cancer vaccine (MVA-Twist-TRICOM) can also be used effectively to inhibit lung metastasis of breast cancer by increasing the infiltration of CD4+CD8+ T cells and the production of IFN-γ and TNF-α (130). Here, CD4 is linked to breast carcinoma.