have demonstrated that the high expression of TIM-3 is associated with head and neck squamous cell carcinoma lymph node metastasis and that the mAb targeting TIM-3 can be used to restore the function of CD4+TIM-3+ and CD8+TIM-3+ T cells to inhibit tumor growth and metastasis (62). This evidence concerns the gene HAVCR2 and head and neck squamous cell carcinoma.