Regarding the antitumor function of TNFSF14, considerable progress has been achieved through studies using animal models with the aim to explore the therapeutic effect of the anti-TNFSF14 mAb LIGHT-VTR in combination with an anti-PD-1 mAb; favorable results have been reported in the reduction of lung cancer metastasis (124). The gene discussed is PDCD1; the disease is lung cancer.