VTCN1 is a kind of transmembrane protein with 282 amino acids, consisting of a transmembrane domain, a two amino acid intracellular domain and seven N-glycosylation site extracellular domain (78), which is a type of minority immune checkpoint that is expressed on the surface of tumor cells like serum ovarian cancer and breast cancer (79). Here, VTCN1 is linked to neoplasm.