1 inhibits the proliferation and activation of T cells and the secretion of some cytokines like IFN-γ and TNF-α2 The decreased expression of CD276 will lead to the tumor-metastasis-related protein MMP-2, STAT3, IL-8 get reduced signals3 CD276 can work with PD-1 and CTLA-4. The gene discussed is STAT3; the disease is neoplasm.