The excessive degradation of various cancer suppressor factors and the activation of cancer-related pathways lead to the activation of NF-κB downstream effectors and form a positive feedback loop, enhancing the cell signal transmission in the BM microenvironment and the survival rate of MM cells, ultimately leading to the quick malignancy profiling of myeloma cells (36, 37). Here, NFKB1 is linked to Miyoshi myopathy.