Given the importance of the proteasome in MM biology and therapy, we further explored the relationship between PSMB7 and ISS status of NDMM and found that the expression of PSMB7 in ISS III was significantly higher than in ISS I/II, which means that PSMB7 was not only positively correlated with the malignant degree of PC dyscrasia, and it was also correlated with the ISS status of NDMM. This evidence concerns the gene PSMB7 and Miyoshi myopathy.