Transducing of Human CRC cells (HCT116 cells) with small hairpin RNA (shRNA) targeting NUFIP1, FAM92A1, NEBL, PLEKHS1, PRPF4, CGREF1, POLR1B, HILPDA, TAF1D, or NUDCD1 attenuated growth. The gene discussed is PLEKHS1; the disease is colorectal carcinoma.