The biological function of NUFIP1 in CRC had never been explored, our current study for the first time revealed that NUFIP1 knockdown significantly suppressed CRC cell growth both in vitro and in vivo by inhibiting cell proliferation and inducing cell apoptosis, while NUFIP1 overexpression had a minor effect on promoting cell proliferation in Caco2 cell (unpublished data), suggesting the essential role of NUFIP1 on tumor growth. This evidence concerns the gene NUFIP1 and neoplasm.