Transducing of Human CRC cells (HCT116 cells) with small hairpin RNA (shRNA) targeting NUFIP1, FAM92A1, NEBL, PLEKHS1, PRPF4, CGREF1, POLR1B, HILPDA, TAF1D, or NUDCD1 attenuated growth. Here, POLR1B is linked to colorectal carcinoma.