Wang et al. (113) disrupted HOTAIR-EZH2 with PNA3 in combination with DNMTi and found that the tumor initiation and stem cell frequency of ovarian cancer stem cells were inhibited, suggesting that dual inhibition of HOTAIR-EZH2 interaction and DNA methylation may be a potent strategy to eradicate ovarian cancer stem cells. The gene discussed is EZH2; the disease is ovarian carcinoma.