Some potential predictive biomarkers have been identified up to now, such as tumor mutational burden (TMB), mismatch repair deficiency (dMMR), immune cell infiltration, and inhibitory receptors related gene expression such as PD-1, PD-L1, CTLA-4, LAG-3, TIM3, and TIGIT (22, 23). This evidence concerns the gene CD274 and neoplasm.