Some potential predictive biomarkers have been identified up to now, such as tumor mutational burden (TMB), mismatch repair deficiency (dMMR), immune cell infiltration, and inhibitory receptors related gene expression such as PD-1, PD-L1, CTLA-4, LAG-3, TIM3, and TIGIT (22, 23). Here, HAVCR2 is linked to neoplasm.