The results indicated that expression of GMFG was lower in bladder urothelial carcinoma, breast cancer, colon adenocarcinoma, kidney chromophobe, lung adenocarcinoma, lung squamous cell carcinoma, liver hepatocellular carcinoma, pancreatic adenocarcinoma, rectum adenocarcinoma and uterine corpus endometrial carcinoma than in normal tissues. The gene discussed is GMFG; the disease is chromophobe renal cell carcinoma.